Philo Hermans went deep into Livewire optimizations in his talk. A couple of key takeaways:

If your Livewire component calls an action that doesn’t need to re-render anything, you can skip re-rendering by using the [Renderless] attribute. I think I can find some immediate use cases for this.

For high-traffic apps with read replica databases, the sticky option can help guarantee consistency immediately after writes.

Optimistic UIs can improve perceived efficiency: use wire:loading.remove to immediately remove an element before the server round-trip has completed, so the app feels more snappy. I think I could also improve some UIs using this trick.